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In addition to this, studies in animal models have suggested that activating the GLP-1Rs in the brain improves neuroinflammation and neurogenesis and confers neuroprotection [46,80,120,121]

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However, statistical significance was sensitive to the exclusion of individual trials, especially Blackman et al

Rates at the 2 mg dose, studied in SUSTAIN FORTE, were similar to the 1 mg arm for eructation specifically, though total GI adverse event burden was modestly higher